Abstract
A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.
MeSH terms
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Cathepsin C / antagonists & inhibitors*
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Humans
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Indicators and Reagents
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Models, Molecular
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Molecular Conformation
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / pharmacology*
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Recombinant Proteins / chemistry
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Spectrometry, Fluorescence
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Structure-Activity Relationship
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Substrate Specificity
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X-Ray Diffraction
Substances
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Indicators and Reagents
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Protease Inhibitors
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Recombinant Proteins
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Cathepsin C