MYC, MAX, and small cell lung cancer

Cancer Discov. 2014 Mar;4(3):273-4. doi: 10.1158/2159-8290.CD-14-0069.

Abstract

In this issue of Cancer Discovery, Romero and colleagues identify somatic mutations and deletions of MAX, and also define what seem to be mutually exclusive alterations in MYC family members and other MYC-associated factors in small cell lung cancer. Taken together, these data highlight the importance of MYC signaling in small cell lung cancer and suggest possible avenues for therapeutic intervention.

Publication types

  • Comment

MeSH terms

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics*
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • DNA Helicases / metabolism*
  • Humans
  • Lung Neoplasms / genetics*
  • Nuclear Proteins / metabolism*
  • Small Cell Lung Carcinoma / genetics*
  • Transcription Factors / metabolism*

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Basic Helix-Loop-Helix Transcription Factors
  • MAX protein, human
  • MGA protein, human
  • Nuclear Proteins
  • Transcription Factors
  • SMARCA4 protein, human
  • DNA Helicases