A polyomavirus tumor-specific transplantation antigen (TSTA) epitope is situated within the N-terminal amino acid sequence common to middle and small T-antigens

Virology. 1988 Oct;166(2):616-9. doi: 10.1016/0042-6822(88)90537-5.

Abstract

An MT cDNA-transformed rat cell line (2.8), that contains only the polyoma middle T-antigen and expresses polyoma TSTA, can be rejected in rats immunized with 1837 cells that carry a host range (A185 hr-t), mutant which expresses a full-length large T-antigen, and nonfunctional N-terminal fragments of small and middle T. This shows that at least one polyoma TSTA epitope is situated in the 113 amino acid N-terminal region, which is common to middle and small T-antigens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Polyomavirus Transforming / genetics
  • Antigens, Polyomavirus Transforming / immunology*
  • Antigens, Surface / genetics
  • Antigens, Surface / immunology
  • Cell Line
  • DNA, Viral / genetics
  • Epitopes
  • Immunization
  • Neoplasms, Experimental / genetics
  • Neoplasms, Experimental / microbiology
  • Polyomavirus / genetics
  • Polyomavirus / immunology*
  • Rats

Substances

  • Antigens, Polyomavirus Transforming
  • Antigens, Surface
  • DNA, Viral
  • Epitopes