High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma

Yi-An Zhang; Ji-Min Zhu; Jie Yin; Wen-Qing Tang; Yan-Mei Guo; Xi-Zhong Shen; Tao-Tao Liu

doi:10.1371/journal.pone.0090955

High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma

PLoS One. 2014 Mar 7;9(3):e90955. doi: 10.1371/journal.pone.0090955. eCollection 2014.

Authors

Yi-An Zhang¹, Ji-Min Zhu¹, Jie Yin¹, Wen-Qing Tang¹, Yan-Mei Guo², Xi-Zhong Shen¹, Tao-Tao Liu³

Affiliations

¹ Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
² Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
³ Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.

Abstract

Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / genetics*
Biomarkers, Tumor / metabolism
Carcinoma, Hepatocellular / genetics*
Carcinoma, Hepatocellular / mortality
Carcinoma, Hepatocellular / pathology
Carcinoma, Hepatocellular / surgery
Cell Line, Tumor
Cell Movement
Cell Proliferation
Female
Follow-Up Studies
Gene Expression
Humans
Liver Neoplasms / genetics*
Liver Neoplasms / metabolism
Liver Neoplasms / pathology
Middle Aged
Neoplasm Recurrence, Local / genetics*
Neoplasm Recurrence, Local / mortality
Neoplasm Recurrence, Local / pathology
Neoplasm Recurrence, Local / surgery
Neuro-Oncological Ventral Antigen
Prognosis
RNA, Small Interfering / genetics
RNA, Small Interfering / metabolism
RNA-Binding Proteins / antagonists & inhibitors
RNA-Binding Proteins / genetics*
RNA-Binding Proteins / metabolism
Survival Analysis

Substances

Biomarkers, Tumor
NOVA1 protein, human
Neuro-Oncological Ventral Antigen
RNA, Small Interfering
RNA-Binding Proteins

Grants and funding

This study was supported by the Shanghai Science and Technology Commission (10410709400, 10411950100), National Nature Science Foundation of China (81000968, 81101540, 81101637 and 81172273), the National Clinical Key Special Subject of China and China Postdoctoral Science Foundation funded project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.