Abstract
Single cases of B- and T-lymphoblastic leukemia/lymphoma occurring after remission of JMML, and JMML occurring after remission of B-lymphoblastic leukemia have been reported in the literature. We present a unique case of a child with concurrent JMML and T-lymphoblastic lymphoma in which an identical missense mutation in NRAS was found in both the neoplastic JMML and T-LBL cells. JMML has been considered a stem cell disorder, and our case provides additional molecular evidence for a stem cell lesion underlying the two different disease phenotypes.
Keywords:
BMT for malignant conditions; JMML; lymphoblastic lymphoma.
© 2013 Wiley Periodicals, Inc.
MeSH terms
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Bone Marrow Transplantation
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Child, Preschool
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Cytogenetic Analysis
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GTP Phosphohydrolases / genetics*
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Humans
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Leukemia, Myelomonocytic, Juvenile / diagnosis
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Leukemia, Myelomonocytic, Juvenile / genetics*
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Leukemia, Myelomonocytic, Juvenile / therapy
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Male
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Membrane Proteins / genetics*
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Mutation, Missense / genetics*
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Neoplasms, Multiple Primary / diagnosis
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Neoplasms, Multiple Primary / genetics*
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Neoplasms, Multiple Primary / therapy
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / therapy
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Prognosis
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Transplantation Conditioning
Substances
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Membrane Proteins
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GTP Phosphohydrolases
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NRAS protein, human