Abstract
A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10-50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antimalarials / isolation & purification*
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Antimalarials / metabolism
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Antimalarials / pharmacology*
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Australia
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification*
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Depsipeptides / pharmacology*
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Drug Resistance, Multiple / drug effects
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Inhibitory Concentration 50
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Marine Biology
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plasmodium falciparum / drug effects*
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology*
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Streptomyces / chemistry*
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Streptomyces / genetics
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antimalarials
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Depsipeptides
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Polyketides
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mollemycin A