Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1802-4. doi: 10.1016/j.bmcl.2014.02.022. Epub 2014 Feb 22.

Abstract

Three new pyrrolobenzodiazepine derivatives, boseongazepines A-C (1-3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1-4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines.

Keywords: Boseongazepines; Cytotoxicity; Pyrrolobenzodiazepine; Streptomyces.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Benzodiazepines / chemistry
  • Benzodiazepines / isolation & purification
  • Benzodiazepines / pharmacology*
  • Benzodiazepinones / chemistry
  • Benzodiazepinones / isolation & purification
  • Benzodiazepinones / pharmacology*
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Hep G2 Cells
  • Humans
  • Jurkat Cells
  • K562 Cells
  • Molecular Conformation
  • Pyrroles / chemistry
  • Pyrroles / isolation & purification
  • Pyrroles / pharmacology*
  • Streptomyces / chemistry*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Benzodiazepinones
  • Pyrroles
  • boseongazepine C
  • pyrrolo(2,1-c)(1,4)benzodiazepine
  • Benzodiazepines