Abstract
Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Brain Neoplasms* / metabolism
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Brain Neoplasms* / pathology
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Cell Line, Tumor
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Contrast Media* / pharmacokinetics
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Contrast Media* / pharmacology
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Drug Delivery Systems / methods*
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Glioma* / metabolism
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Glioma* / pathology
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Gold* / pharmacokinetics
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Gold* / pharmacology
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Heterografts
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Humans
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Lasers*
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Metal Nanoparticles*
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Mice
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Neoplasm Transplantation