General and abdominal fat outcomes in school-age children associated with infant breastfeeding patterns

Am J Clin Nutr. 2014 Jun;99(6):1351-8. doi: 10.3945/ajcn.113.075937. Epub 2014 Mar 12.

Abstract

Background: Breastfeeding may have a protective effect on the development of obesity in later life. Not much is known about the effects of infant feeding on more-specific fat measures.

Objective: We examined associations of breastfeeding duration and exclusiveness and age at the introduction of solid foods with general and abdominal fat outcomes in children.

Design: We performed a population-based, prospective cohort study in 5063 children. Information about infant feeding was obtained by using questionnaires. At the median age of 6.0 y (95% range: 5.7 y, 6.8 y), we measured childhood anthropometric measures, total fat mass and the android:gynoid fat ratio by using dual-energy X-ray absorptiometry, and preperitoneal abdominal fat by using ultrasound.

Results: We observed that, in the models adjusted for child age, sex, and height only, a shorter breastfeeding duration, nonexclusive breastfeeding, and younger age at the introduction of solid foods were associated with higher childhood general and abdominal fat measures (P-trend < 0.05) but not with higher childhood body mass index. The introduction of solid foods at a younger age but not breastfeeding duration or exclusivity was associated with higher risk of overweight or obesity (OR: 2.05; 95% CI: 1.41, 2.90). After adjustment for family-based sociodemographic, maternal lifestyle, and childhood factors, the introduction of solid food between 4 and 4.9 mo of age was associated with higher risks of overweight or obesity, but the overall trend was not significant.

Conclusions: Associations of infant breastfeeding and age at the introduction of solid foods with general and abdominal fat outcomes are explained by sociodemographic and lifestyle-related factors. Whether infant dietary composition affects specific fat outcomes at older ages should be further studied.

Publication types

  • Comparative Study
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Fat / growth & development
  • Abdominal Fat / pathology
  • Adipogenesis
  • Adipose Tissue / growth & development
  • Adipose Tissue / pathology*
  • Adiposity*
  • Breast Feeding*
  • Child
  • Child Development
  • Child, Preschool
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant Food*
  • Infant Nutritional Physiological Phenomena*
  • Male
  • Netherlands / epidemiology
  • Obesity / epidemiology*
  • Obesity / pathology
  • Overweight / epidemiology*
  • Overweight / pathology
  • Prospective Studies
  • Risk
  • Surveys and Questionnaires