Abstract
We treated 94 patients with advanced head and neck cancer with a combined-modality protocol that included induction chemotherapy followed by surgery with and without radiotherapy. With a minimum follow-up of 3 1/2 years, 33 (35%) of the patients were alive and disease free. Thirty (32%) of the patients died of recurrent head and neck cancer. Complete response to chemotherapy and initial tumor bulk correlated with prolonged disease-free survival. Site of disease had no effect. There appeared to be no advantage to the use of routine postoperative radiotherapy in these advanced tumors.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / therapy
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Cisplatin / administration & dosage
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Clinical Protocols
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Combined Modality Therapy
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Female
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Follow-Up Studies
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Head and Neck Neoplasms / drug therapy*
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Head and Neck Neoplasms / mortality
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Head and Neck Neoplasms / therapy
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Humans
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Male
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Pilot Projects
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Postoperative Care
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Time Factors
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Vincristine / administration & dosage
Substances
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Bleomycin
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Vincristine
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Cisplatin