Abstract
The pathomorphism of rectal cancer (RC) was studied in 99 patients who received neoadjuvant chemoradiotherapy using two drugs (5-fluorouracil and xeloda). A morphological study indicated the qualitatively similar manifestations of pathomorphism (tumor necrosis, inflammation, and sclerosis) which were more pronounced in the use of xeloda. Three degrees of the pathomorphism of RC have been identified: the tumor was unchanged, changed, and undetectable.
MeSH terms
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Adult
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Capecitabine
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Cell Proliferation / drug effects
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Chemoradiotherapy
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Deoxycytidine / administration & dosage
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Deoxycytidine / adverse effects
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Deoxycytidine / analogs & derivatives*
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Female
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Fluorouracil / administration & dosage*
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Fluorouracil / adverse effects
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Fluorouracil / analogs & derivatives*
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Humans
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Male
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Middle Aged
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Neoadjuvant Therapy*
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Neoplasm Staging
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Rectal Neoplasms / drug therapy*
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Rectal Neoplasms / pathology
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Rectal Neoplasms / radiotherapy
Substances
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Deoxycytidine
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Capecitabine
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Fluorouracil