Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

G Draetta; H Piwnica-Worms; D Morrison; B Druker; T Roberts; D Beach

doi:10.1038/336738a0

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Nature. 1988 Dec;336(6201):738-44. doi: 10.1038/336738a0.

Authors

G Draetta¹, H Piwnica-Worms, D Morrison, B Druker, T Roberts, D Beach

Affiliation

¹ Cold Spring Harbor Laboratory, New York 11724.

PMID: 2462672
DOI: 10.1038/336738a0

Abstract

cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

CDC2 Protein Kinase
Cell Cycle*
HeLa Cells
Mitosis
Phosphoproteins / metabolism*
Phosphotyrosine
Protein-Tyrosine Kinases / metabolism*
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins pp60(c-src)
Tyrosine / analogs & derivatives
Tyrosine / metabolism

Substances

Phosphoproteins
Proto-Oncogene Proteins
Phosphotyrosine
Tyrosine
Protein-Tyrosine Kinases
Proto-Oncogene Proteins pp60(c-src)
CDC2 Protein Kinase