Efficacy of afoxolaner against Dermacentor variabilis ticks in dogs

Vet Parasitol. 2014 Apr 2;201(3-4):220-2. doi: 10.1016/j.vetpar.2014.02.016. Epub 2014 Mar 13.

Abstract

Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Dermacentor variabilis ticks was confirmed in two laboratory studies. Each study utilized a controlled, randomized block design. One day prior to treatment, beagle dogs were infested with 50 unfed adult ticks. Repeat infestations were performed weekly for four weeks. The number of live ticks remaining on each dog was determined 48 h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations by D. variabilis ticks and controlled weekly re-infestations with 99.7-100% efficacy up to Day 23 and >97% efficacy at Day 30.

Keywords: Afoxolaner; Dermacentor variabilis; Dogs; Ticks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acaricides / administration & dosage*
  • Animals
  • Dermacentor / physiology*
  • Dog Diseases / drug therapy*
  • Dog Diseases / prevention & control
  • Dogs
  • Female
  • Male
  • Random Allocation
  • Tick Infestations / drug therapy
  • Tick Infestations / prevention & control
  • Tick Infestations / veterinary*
  • Treatment Outcome

Substances

  • Acaricides