Evaluation of the efficacy of afoxolaner against Haemaphysalis longicornis on dogs

Vet Parasitol. 2014 Apr 2;201(3-4):229-31. doi: 10.1016/j.vetpar.2014.02.019. Epub 2014 Mar 13.

Abstract

A controlled study to assess the acaricidal efficacy of afoxolaner in dogs after a single oral administration was conducted against Haemaphysalis longicornis ticks. The study was characterized by a negative controlled randomized block design and included sixteen beagle dogs of both sexes. Starting two days before treatment, each dog was infested weekly with 50 ticks over 4 weeks. The number of live ticks was determined 48 h after treatment and then 48 h after each infestation. The mean dose of afoxolaner received by dogs was 3.0mg/kg (range: 2.5-3.1mg/kg). Afoxolaner rapidly eliminated pre-existing tick infestations (100% ticks killed within 48 h of treatment) and controlled weekly re-infestations (91.9% prophylactic efficacy at Day 30).

Keywords: Afoxolaner; Dog; Efficacy; Haemaphysalis longicornis; Tick.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acaricides / therapeutic use*
  • Animals
  • Dog Diseases / drug therapy*
  • Dog Diseases / prevention & control
  • Dogs
  • Female
  • Isoxazoles / administration & dosage*
  • Ixodidae*
  • Male
  • Naphthalenes / administration & dosage*
  • Random Allocation
  • Tick Infestations / drug therapy
  • Tick Infestations / prevention & control
  • Tick Infestations / veterinary*
  • Treatment Outcome

Substances

  • Acaricides
  • Isoxazoles
  • Naphthalenes
  • afoxolaner