Intra-venous chlorpromazine with fluid treatment in status migrainosus

Uygar Utku; Mustafa Gokce; Elif Muruvvet Benli; Aytaç Dinc; Deniz Tuncel

doi:10.1016/j.clineuro.2014.01.002

Intra-venous chlorpromazine with fluid treatment in status migrainosus

Clin Neurol Neurosurg. 2014 Apr:119:4-5. doi: 10.1016/j.clineuro.2014.01.002. Epub 2014 Jan 10.

Authors

Uygar Utku¹, Mustafa Gokce², Elif Muruvvet Benli², Aytaç Dinc², Deniz Tuncel²

Affiliations

¹ Department of Neurology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 46050 Kahramanmaras, Turkey. Electronic address: [email protected].
² Department of Neurology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 46050 Kahramanmaras, Turkey.

PMID: 24635917
DOI: 10.1016/j.clineuro.2014.01.002

Abstract

Objective: To present the results of the intra-venous chlorpromazine with fluid treatment in patients with status migrainosus.

Methods: Consecutive 21 patients with status migrainosus were received intra-venous chlorpromazine (maximum 25mg) with fluid treatment and their results were documented.

Results: Complete recovery of headache and nausea were seen in 20/21 and 17/21 of the patients respectively. 15/21 of patients were headache free following at 10mg chlorpromazine infusion. Most patients went on sleep after 10mg chlorpromazine infusion and when they wake already up headache free. Side effects such as tachycardia, palpitation, flushing and hypertension were seen only one of 21 patients following first dose 5mg injection.

Conclusions: This study showed that intra-venous chlorpromazine with fluid treatment for status migrainosus seems a good option.

Keywords: Acute headache treatment; Intra-venous chlorpromazine; Status migrainosus.

MeSH terms

Administration, Intravenous
Adult
Antiemetics / therapeutic use*
Chlorpromazine / therapeutic use*
Cohort Studies
Female
Fluid Therapy / methods*
Humans
Male
Migraine Disorders / therapy*
Prospective Studies
Treatment Outcome

Substances

Antiemetics
Chlorpromazine