Urinary intestinal fatty acid binding protein predicts necrotizing enterocolitis

Katherine E Gregory; Abigail B Winston; Hidemi S Yamamoto; Hassan Y Dawood; Titilayo Fashemi; Raina N Fichorova; Linda J Van Marter

doi:10.1016/j.jpeds.2014.01.057

Urinary intestinal fatty acid binding protein predicts necrotizing enterocolitis

J Pediatr. 2014 Jun;164(6):1486-8. doi: 10.1016/j.jpeds.2014.01.057. Epub 2014 Mar 15.

Authors

Katherine E Gregory¹, Abigail B Winston², Hidemi S Yamamoto³, Hassan Y Dawood³, Titilayo Fashemi³, Raina N Fichorova⁴, Linda J Van Marter⁵

Affiliations

¹ W.F. Connell School of Nursing, Boston College, Chestnut Hill, MA; Department of Nursing, Brigham and Women's Hospital, Boston, MA; Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address: [email protected].
² Division of Newborn Medicine, Boston Children's Hospital, Boston, MA.
³ The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.
⁴ The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
⁵ Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA; The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.

Abstract

Necrotizing enterocolitis, characterized by sudden onset and rapid progression, remains the most significant gastrointestinal disorder among premature infants. In seeking a predictive biomarker, we found intestinal fatty acid binding protein, an indicator of enterocyte damage, was substantially increased within three and seven days before the diagnosis of necrotizing enterocolitis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers / urine
Birth Weight
Cohort Studies
Disease Progression
Enterocolitis, Necrotizing / physiopathology*
Enterocolitis, Necrotizing / urine*
Fatty Acid-Binding Proteins / urine*
Female
Gestational Age
Hospitals, Pediatric
Humans
Infant, Newborn
Infant, Premature*
Male
Odds Ratio
Predictive Value of Tests
Prognosis
ROC Curve
Retrospective Studies
Risk Assessment
Severity of Illness Index
Statistics, Nonparametric

Substances

Biomarkers
Fatty Acid-Binding Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding