Synthesis of PEGylated low generation dendrimer-entrapped gold nanoparticles for CT imaging applications

Nanoscale. 2014 May 7;6(9):4521-6. doi: 10.1039/c3nr06694k.

Abstract

Dendrimer-entrapped gold nanoparticles (Au DENPs) can be formed using low-generation dendrimers pre-modified by polyethylene glycol (PEG). The formed PEGylated Au DENPs with desirable stability, cytocompatibility, and X-ray attenuation properties enable efficient computed tomography imaging of the heart and tumor model of mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media / chemical synthesis*
  • Contrast Media / chemistry
  • Dendrimers / chemistry*
  • Gold / chemistry*
  • Heart / diagnostic imaging
  • Metal Nanoparticles / chemistry*
  • Mice
  • Neoplasms / diagnosis
  • Neoplasms / diagnostic imaging
  • Polyethylene Glycols / chemistry*
  • Tomography, X-Ray Computed
  • Urinary Bladder / diagnostic imaging

Substances

  • Contrast Media
  • Dendrimers
  • Polyethylene Glycols
  • Gold