Human cathelicidin LL-37 resistance and increased daptomycin MIC in methicillin-resistant Staphylococcus aureus strain USA600 (ST45) are associated with increased mortality in a hospital setting

J Clin Microbiol. 2014 Jun;52(6):2172-4. doi: 10.1128/JCM.00189-14. Epub 2014 Mar 19.

Abstract

Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virulent health care-associated MRSA strains may coevolve innate host defense peptide and antibiotic resistances.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Antimicrobial Cationic Peptides / pharmacology*
  • Bacteremia / microbiology
  • Bacteremia / mortality
  • Cathelicidins
  • Cross Infection / microbiology
  • Cross Infection / mortality*
  • Daptomycin / pharmacology*
  • Drug Resistance, Bacterial*
  • Hospitals
  • Humans
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Microbial Sensitivity Tests
  • Microbial Viability / drug effects
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / mortality*
  • United States

Substances

  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides
  • Daptomycin
  • Cathelicidins