Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8

Leukemia. 2014 Aug;28(8):1754-1758. doi: 10.1038/leu.2014.114. Epub 2014 Mar 21.

Authors

Heiko Becker¹, Kati Maharry^{1

2}, Krzysztof Mrózek¹, Stefano Volinia¹, Ann-Kathrin Eisfeld¹, Michael D Radmacher¹, Jessica Kohlschmidt^{1

2}, Klaus H Metzeler¹, Sebastian Schwind¹, Susan P Whitman¹, Jason H Mendler¹, Yue-Zhong Wu¹, Deedra Nicolet¹, Peter Paschka¹, Bayard L Powell³, Thomas H Carter⁴, Meir Wetzler⁵, Jonathan E Kolitz⁶, Andrew J Carroll⁷, Maria R Baer⁸, Michael A Caligiuri¹, Richard M Stone⁹, Guido Marcucci^#¹, Clara D Bloomfield^#¹

Affiliations

¹ The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
² Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN, USA.
³ Comprehensive Cancer Center, Wake Forest University, Winston-Salem, NC, USA.
⁴ Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
⁵ Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
⁶ Monter Cancer Center, Hofstra North Shore-Long Island Jewish School of Medicine, Lake Success, NY, USA.
⁷ Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
⁸ Department of Medicine and Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA.
⁹ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Chromosomes, Human, Pair 8*
DNA-Binding Proteins / genetics
Dioxygenases
Disease-Free Survival
Female
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / mortality
Male
MicroRNAs / analysis*
Middle Aged
Mutation*
Prognosis
Proto-Oncogene Proteins / genetics
Trisomy*
fms-Like Tyrosine Kinase 3 / genetics

Substances

DNA-Binding Proteins
MicroRNAs
Proto-Oncogene Proteins
Dioxygenases
TET2 protein, human
FLT3 protein, human
fms-Like Tyrosine Kinase 3

Grants and funding