Ultrasensitive dopamine sensor based on novel molecularly imprinted polypyrrole coated carbon nanotubes

Biosens Bioelectron. 2014 Aug 15:58:237-41. doi: 10.1016/j.bios.2014.02.081. Epub 2014 Mar 12.

Abstract

A novel electrochemical sensor using the molecularly imprinted (MIP) oxygen-containing polypyrrole (PPy) decorated carbon nanotubes (CNTs) composite was proposed for in vivo detection of dopamine (DA). The prepared sensor exhibits a remarkable sensitivity of (16.18μA/μM) with a linear range of 5.0×10(-11)-5.0×10(-6)M and limit of detection as low as 1.0×10(-11)M in the detection of DA, which might be due to the plenty cavities for binding DA through π-π stacking between aromatic rings and hydrogen bonds between amino groups of DA and oxygen-containing groups of the novel PPy.

Keywords: Carbon nanotubes; Dopamine; Electrochemical sensor; Molecularly imprinted polymers; Polypyrrole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coated Materials, Biocompatible / chemical synthesis*
  • Conductometry / instrumentation*
  • Dopamine / analysis*
  • Dopamine / chemistry
  • Equipment Design
  • Equipment Failure Analysis
  • Microchemistry / instrumentation*
  • Molecular Imprinting / instrumentation
  • Molecular Imprinting / methods*
  • Nanotubes, Carbon / chemistry*
  • Nanotubes, Carbon / ultrastructure
  • Polymers / chemistry*
  • Pyrroles / chemistry*
  • Surface Properties

Substances

  • Coated Materials, Biocompatible
  • Nanotubes, Carbon
  • Polymers
  • Pyrroles
  • polypyrrole
  • Dopamine