Regulation of LRP-1 expression: make the point

H Emonard; L Théret; A H Bennasroune; S Dedieu

doi:10.1016/j.patbio.2014.02.002

Regulation of LRP-1 expression: make the point

Pathol Biol (Paris). 2014 Apr;62(2):84-90. doi: 10.1016/j.patbio.2014.02.002. Epub 2014 Mar 21.

Authors

H Emonard¹, L Théret¹, A H Bennasroune¹, S Dedieu²

Affiliations

¹ UMR CNRS 7369, unité MEDyC (matrice extracellulaire et dynamique cellulaire), université de Reims-Champagne-Ardenne (URCA), UFR sciences exactes et naturelles, campus Moulin-de-la-Housse, BP 1039, 51687 Reims cedex 2, France.
² UMR CNRS 7369, unité MEDyC (matrice extracellulaire et dynamique cellulaire), université de Reims-Champagne-Ardenne (URCA), UFR sciences exactes et naturelles, campus Moulin-de-la-Housse, BP 1039, 51687 Reims cedex 2, France. Electronic address: [email protected].

PMID: 24661974
DOI: 10.1016/j.patbio.2014.02.002

Abstract

The low-density lipoprotein receptor-related protein-1 (LRP-1) is a membrane receptor displaying both scavenging and signaling functions. The wide variety of extracellular ligands and of cytoplasmic scaffolding and signaling proteins interacting with LRP-1 gives it a major role not only in physiological processes, such as embryogenesis and development, but also in critical pathological situations, including cancer and neurological disorders. In this review, we describe the molecular mechanisms involved at distinct levels in the regulation of LRP-1, from its expression to the proper location and stability at the cell surface.

Keywords: Endocytose; Endocytosis; LRP-1; Protéolyse; Shedding; Signaling; Signalisation.

Publication types

Review

MeSH terms

Animals
Cell Membrane / metabolism
Cellular Microenvironment
Disease Progression
Endocytosis / physiology
Gene Expression Regulation
Gene Expression Regulation, Neoplastic
Humans
Ligands
Low Density Lipoprotein Receptor-Related Protein-1 / biosynthesis
Low Density Lipoprotein Receptor-Related Protein-1 / chemistry
Low Density Lipoprotein Receptor-Related Protein-1 / genetics
Low Density Lipoprotein Receptor-Related Protein-1 / physiology*
Mice
Models, Molecular
Neoplasm Proteins / physiology
Neoplasms / pathology
Peptide Hydrolases / metabolism
Phosphorylation
Protein Conformation
Protein Folding
Protein Processing, Post-Translational
Protein Transport
Signal Transduction / physiology
Structure-Activity Relationship

Substances

LRP1 protein, human
Ligands
Low Density Lipoprotein Receptor-Related Protein-1
Neoplasm Proteins
Peptide Hydrolases