Abstract
Ivorenolide B (1), an unprecedented 17-membered macrolide featuring conjugated acetylenic bonds and four chiral centers, was isolated from Khaya ivorensis. The structure of 1 was fully determined by spectroscopic analysis and total syntheses of its four most possible stereoisomers. Compound 1 showed significant immunosuppressive activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / isolation & purification*
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Immunosuppressive Agents / pharmacology*
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology*
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Meliaceae / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Stereoisomerism
Substances
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Immunosuppressive Agents
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Macrolides
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ivorenolide B