Comparison of a human T-cell lymphotropic virus type I strain from cerebrospinal fluid of a Jamaican patient with tropical spastic paraparesis with a prototype human T-cell lymphotropic virus type I

Proc Natl Acad Sci U S A. 1989 Mar;86(6):2021-5. doi: 10.1073/pnas.86.6.2021.

Abstract

The isolation and characterization of a human T-cell lymphotropic retrovirus related to human T-cell lymphotropic virus type I (HTLV-I) from cerebrospinal fluid of a Jamaican patient with tropical spastic paraparesis is described. The virus isolate is a typical type C retrovirus as seen by electron microscopy and is related to prototype HTLV-I isolated from patients with adult T-cell leukemia but is not identical to this prototype HTLV-I as seen by restriction enzyme mapping.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Aged
  • Cells, Cultured
  • Cerebrospinal Fluid / microbiology*
  • DNA Restriction Enzymes
  • DNA, Viral / analysis
  • Deltaretrovirus Antibodies / analysis
  • Female
  • Fluorescent Antibody Technique
  • Human T-lymphotropic virus 1 / enzymology
  • Human T-lymphotropic virus 1 / genetics
  • Human T-lymphotropic virus 1 / isolation & purification*
  • Humans
  • Jamaica
  • Leukemia, T-Cell / microbiology
  • Leukocytes, Mononuclear / microbiology
  • Microscopy, Electron
  • Paraparesis, Tropical Spastic / immunology
  • Paraparesis, Tropical Spastic / microbiology*
  • RNA-Directed DNA Polymerase / analysis

Substances

  • DNA, Viral
  • Deltaretrovirus Antibodies
  • RNA-Directed DNA Polymerase
  • DNA Restriction Enzymes