Evaluation of a metal artifact reduction technique in tonsillar cancer delineation

Jonathan A Abelson; James D Murphy; Ellen A Wiegner; Deborah Abelson; David N Sandman; F Edward Boas; Dimitre Hristov; Dominik Fleischmann; Megan E Daly; Daniel T Chang; Billy W Loo Jr; Wendy Hara; Quynh-Thu Le

doi:10.1016/j.prro.2011.06.004

Evaluation of a metal artifact reduction technique in tonsillar cancer delineation

Pract Radiat Oncol. 2012 Jan-Mar;2(1):27-34. doi: 10.1016/j.prro.2011.06.004. Epub 2011 Jul 20.

Affiliations

¹ Department of Radiation Oncology, Stanford University, Stanford, California.
² Department of Radiology, Stanford University, Stanford, California.
³ Department of Radiology, University of California, San Francisco, California.
⁴ Department of Radiation Oncology, Stanford University, Stanford, California. Electronic address: [email protected].

PMID: 24674033
DOI: 10.1016/j.prro.2011.06.004

Abstract

Purpose: Metal artifacts can degrade computed tomographic (CT) simulation imaging and impair accurate delineation of tumors for radiation treatment planning purposes. We investigated a Digital Imaging and Communications in Medicine-based metal artifact reduction technique in tonsillar cancer delineation.

Methods and materials: Eight patients with significant artifact and tonsil cancer were evaluated. Each patient had a positron emission tomography (PET)-CT and a contrast-enhanced CT obtained at the same setting during radiotherapy simulation. The CTs were corrected for artifact using the metal deletion technique (MDT). Two radiation oncologists independently delineated primary gross tumor volumes (GTVs) for each patient on native (CTnonMDT), metal corrected (CTMDT), and reference standard (CTPET/nonMDT) imaging, 1 week apart. Mixed effects models were used to determine if differences among GTVs were statistically significant. Two diagnostic radiologists and 2 radiation oncologists independently qualitatively evaluated CTs for each patient. Ratings were on an ordinal scale from -3 to +3, denoting that CTMDT was markedly, moderately, or slightly worse or better than CTnonMDT. Scores were compared with a Wilcoxon signed-rank test.

Results: The GTVPET/nonMDT were significantly smaller than GTVnonMDT (P = .004) and trended to be smaller than GTVMDT (P = .084). The GTVnonMDT and GTVMDT were not significantly different (P = .93). There was no significant difference in the extent to which GTVnonMDT or GTVMDT encompassed GTVPET/nonMDT (P = .33). In the subjective assessment of image quality, CTMDT did not significantly outperform CTnonMDT. In the majority of cases, the observer rated the CTMDT equivalent to (53%) or slightly superior (41%) to the corresponding CTnonMDT.

Conclusions: The MTD modified images did not produce GTVMDT that more closely reproduced GTVPET/nonMDT than did GTVnonMDT. Moreover, the MTD modified images were not judged to be significantly superior when compared to the uncorrected images in terms of subjective ability to visualize the tonsilar tumors. This study failed to demonstrate value of the adjunctive use of a CT corrected for artifacts in the tumor delineation process. Artifacts do make tumor delineation challenging, and further investigation of other body sites is warranted.