A neonatal case of chronic granulomatous disease, initially presented with invasive pulmonary aspergillosis

Sachiko Saito; Arata Oda; Masashi Kasai; Kisei Minami; Haruo Nagumo; Masaaki Shiohara; Yoshifumi Ogiso; Yoshiyuki Kawakami

doi:10.1016/j.jiac.2013.10.008

A neonatal case of chronic granulomatous disease, initially presented with invasive pulmonary aspergillosis

J Infect Chemother. 2014 Mar;20(3):220-3. doi: 10.1016/j.jiac.2013.10.008. Epub 2013 Dec 11.

Authors

Sachiko Saito¹, Arata Oda¹, Masashi Kasai¹, Kisei Minami², Haruo Nagumo¹, Masaaki Shiohara¹, Yoshifumi Ogiso¹, Yoshiyuki Kawakami³

Affiliations

¹ Department of Pediatrics, Nagano Children's Hospital, Azumino, Japan.
² Department of Pediatrics, Nagano Children's Hospital, Azumino, Japan. Electronic address: [email protected].
³ Division of Infection Control and Biological Regulations, Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan.

PMID: 24674387
DOI: 10.1016/j.jiac.2013.10.008

Abstract

Chronic granulomatous disease (CGD) often presents with infectious illness, such as repeating bacterial and fungal infections, due to the inability to generate superoxide, which would destroy certain infectious pathogens, and is usually diagnosed in childhood. We describe a CGD case diagnosed in neonatal period, who initially presented with invasive aspergillosis. Neonatal invasive pulmonary aspergillosis is very rare and, to the best of our knowledge, this might be the youngest case in Japan.

Keywords: Chronic granulomatous disease; Invasive aspergillosis; Neonate.

Publication types

Case Reports

MeSH terms

Age Factors
Antifungal Agents / therapeutic use
Diagnosis, Differential
Female
Granulomatous Disease, Chronic / diagnosis*
Granulomatous Disease, Chronic / microbiology
Humans
Infant, Newborn
Invasive Pulmonary Aspergillosis / diagnosis*
Invasive Pulmonary Aspergillosis / drug therapy

Substances

Antifungal Agents