Abstract
Background/objective:
We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS).
Results:
On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1C and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher in patients with NASH than those without NASH. Following WLS, 40% of patients with NASH had persistently elevated aminotransferase levels despite weight loss.
Conclusion:
We found that NASH is underdiagnosed in adolescents referred for WLS, and that hyperinsulinaemia, HOMA-IR and HbA1c can aid in identifying high-risk patients.
Keywords:
Adolescence; Roux-en-Y gastric bypass; non-alcoholic fatty liver disease; obesity.
© 2014 The Authors. Pediatric Obesity © 2014 International Association for the Study of Obesity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Bariatric Surgery / methods*
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Biomarkers / metabolism
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Body Mass Index
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / epidemiology
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Diabetes Mellitus, Type 2 / pathology*
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Disease Progression
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Female
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Glycated Hemoglobin / metabolism
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Humans
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Insulin Resistance
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Liver / pathology*
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Liver Function Tests
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Male
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Non-alcoholic Fatty Liver Disease / blood
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Non-alcoholic Fatty Liver Disease / epidemiology
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Non-alcoholic Fatty Liver Disease / pathology*
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Obesity, Morbid / blood
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Obesity, Morbid / surgery*
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Prevalence
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Retrospective Studies
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Risk Factors
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Sleep Apnea, Obstructive / epidemiology
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Sleep Apnea, Obstructive / pathology*
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Sleep Apnea, Obstructive / surgery
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Transaminases / metabolism
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Treatment Outcome
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United States / epidemiology
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Weight Loss*
Substances
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Biomarkers
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Glycated Hemoglobin A
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hemoglobin A1c protein, human
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Transaminases