Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists

H Meurs; A F Roffel; J B Postema; A Timmermans; C R Elzinga; H F Kauffman; J Zaagsma

doi:10.1016/0014-2999(88)90331-7

Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists

Eur J Pharmacol. 1988 Nov 1;156(2):271-4. doi: 10.1016/0014-2999(88)90331-7.

Authors

H Meurs¹, A F Roffel, J B Postema, A Timmermans, C R Elzinga, H F Kauffman, J Zaagsma

Affiliation

¹ Department of Pharmacology and Therapeutics, University of Groningen, The Netherlands.

PMID: 2467823
DOI: 10.1016/0014-2999(88)90331-7

Abstract

The relationship between bovine tracheal muscle contraction and phosphoinositide metabolism was studied with the muscarinic agonists, methacholine, oxotremorine, and McN-A-343. Analysis of the dose-response curves for contraction and inositol phosphates accumulation with these agonists demonstrated a direct relationship between the two parameters, with a considerable reserve of inositol phosphate production for the full contractile agonists, methacholine and oxotremorine, and no reserve for the partial agonist, McN-A-343.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride / pharmacology
Animals
Cattle
Inositol Phosphates / metabolism
Methacholine Chloride
Methacholine Compounds / pharmacology
Muscarinic Antagonists*
Muscle Contraction / drug effects*
Muscle, Smooth / drug effects*
Muscle, Smooth / metabolism
Oxotremorine / pharmacology
Phosphatidylinositols / metabolism*
Receptors, Muscarinic / physiology
Trachea / drug effects
Trachea / metabolism

Substances

Inositol Phosphates
Methacholine Compounds
Muscarinic Antagonists
Phosphatidylinositols
Receptors, Muscarinic
Methacholine Chloride
(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride
Oxotremorine