Age and molecular subtypes: impact on surgical decisions

J Surg Oncol. 2014 Jul;110(1):8-14. doi: 10.1002/jso.23604. Epub 2014 Apr 1.

Abstract

Both young patient age and breast cancer molecular subtype impact local recurrence rates and long-term prognosis for women with breast cancer. Although rates of local recurrence are consistently higher in young women and those with high-risk molecular subtypes, this risk does not appear to be overcome by more extensive surgery.

Keywords: age; biologic subtype; breast cancer; local recurrence; surgery.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Breast Neoplasms / classification
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / surgery*
  • Decision Making*
  • Female
  • Humans
  • Prognosis
  • Receptor, ErbB-2 / metabolism*
  • Receptors, Estrogen / metabolism*
  • Receptors, Progesterone / metabolism*

Substances

  • Receptors, Estrogen
  • Receptors, Progesterone
  • Receptor, ErbB-2