Interleukin-28B polymorphisms and response of chronic hepatitis C patients from Indonesia to pegylated interferon/ribavirin treatment

Juniastuti; Bogi P Wibowo; I D N Wibawa; Takako Utsumi; Syifa Mustika; Mochamad Amin; Rury M Wahyuni; Hendra Kurniawan; Agus Hendrayana; Poernomo B Setiawan; Laura N Yamani; Soetjipto; Yoshihiko Yano; Hak Hotta; Yoshitake Hayashi; Maria I Lusida

doi:10.1128/JCM.00768-14

Interleukin-28B polymorphisms and response of chronic hepatitis C patients from Indonesia to pegylated interferon/ribavirin treatment

J Clin Microbiol. 2014 Jun;52(6):2193-5. doi: 10.1128/JCM.00768-14. Epub 2014 Apr 2.

Authors

Juniastuti¹, Bogi P Wibowo², I D N Wibawa³, Takako Utsumi⁴, Syifa Mustika², Mochamad Amin⁵, Rury M Wahyuni⁵, Hendra Kurniawan⁶, Agus Hendrayana⁷, Poernomo B Setiawan⁸, Laura N Yamani⁹, Soetjipto¹⁰, Yoshihiko Yano⁹, Hak Hotta⁹, Yoshitake Hayashi⁹, Maria I Lusida¹¹

Affiliations

¹ Department of Microbiology, School of Medicine, Airlangga University, Surabaya, East Java, Indonesia Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia.
² Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia.
³ Division of Gastroenterohepatology, Department of Internal Medicine, Sanglah General Hospital, Denpasar, Bali, Indonesia.
⁴ Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
⁵ Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia.
⁶ Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia.
⁷ Department of Microbiology, School of Medicine, Udayana University, Denpasar, Bali, Indonesia.
⁸ Department of Internal Medicine, Dr. Soetomo General Hospital, Surabaya, East Java, Indonesia.
⁹ Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
¹⁰ Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia Department of Biochemistry, School of Medicine, Airlangga University, Surabaya, East Java, Indonesia.
¹¹ Department of Microbiology, School of Medicine, Airlangga University, Surabaya, East Java, Indonesia Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia Institute of Tropical Disease, Airlangga University, Surabaya, East Java, Indonesia [email protected].

Abstract

This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Female
Gene Frequency
Genotype
Hepatitis C, Chronic / drug therapy*
Humans
Indonesia
Interferon-alpha / therapeutic use*
Interferons
Interleukins / genetics*
Male
Middle Aged
Polymorphism, Single Nucleotide
Ribavirin / therapeutic use*
Treatment Outcome

Substances

interferon-lambda, human
Interferon-alpha
Interleukins
Ribavirin
Interferons