Evaluation of allelic strength of human TET2 mutations and cooperation between Tet2 knockdown and oncogenic Nras mutation

Br J Haematol. 2014 Aug;166(3):461-5. doi: 10.1111/bjh.12871. Epub 2014 Apr 3.
No abstract available

Keywords: 5hmc; TET2; chronic myelomonocytic leukaemia; oncogenic RAS; whole exome sequencing.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • DNA Mutational Analysis
  • DNA-Binding Proteins / genetics*
  • Dioxygenases
  • Epistasis, Genetic*
  • GTP Phosphohydrolases / genetics*
  • Humans
  • Leukemia / genetics
  • Leukemia / mortality
  • Membrane Proteins / genetics*
  • Mutation*
  • Prognosis
  • Proto-Oncogene Proteins / genetics*

Substances

  • DNA-Binding Proteins
  • Membrane Proteins
  • Proto-Oncogene Proteins
  • Dioxygenases
  • TET2 protein, human
  • GTP Phosphohydrolases
  • NRAS protein, human