This special issue of the Cytokine and Growth Factors Review is devoted to highlighting the exceptional science that was presented at the 14th International TNF Conference held in Québec City, Canada from July 7th to July 10th, 2013. In this beautiful and historic city, approximately 175 delegates gathered to hear and present the latest advances in the TNF superfamily (TNFSF) field across broad subjects such as cancer, signal transduction, tissue homeostasis, cell death and immunity. The science presented in oral and poster format was of the highest caliber, with exciting new stories "breaking" in this exciting inter-disciplinary area of research. We await with anticipation the next (15th) International TNF Conference to be held May 20-23rd, 2015 in Ghent, Belgium. Until then, À Bientôt!.
Keywords: Autoimmunity; Cancer; Fibrosis; Signaling; TNF (Tumor Necrosis Factor); TNFSF (Tumor Necrosis Factor Superfamily).
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