Temporary treatment during primary HIV infection does not affect virologic response to subsequent long-term treatment

Marlous L Grijsen; Ferdinand W N M Wit; Suzanne Jurriaans; Frank P Kroon; Emile F Schippers; Peter Koopmans; Luuk Gras; Joep M A Lange; Jan M Prins; Primo-SHM Study Group

doi:10.1371/journal.pone.0089639

Temporary treatment during primary HIV infection does not affect virologic response to subsequent long-term treatment

PLoS One. 2014 Apr 3;9(4):e89639. doi: 10.1371/journal.pone.0089639. eCollection 2014.

Authors

Marlous L Grijsen¹, Ferdinand W N M Wit², Suzanne Jurriaans³, Frank P Kroon⁴, Emile F Schippers⁵, Peter Koopmans⁶, Luuk Gras⁷, Joep M A Lange², Jan M Prins¹; Primo-SHM Study Group

Collaborators

Primo-SHM Study Group:
J M Prins, J M A Lange, M L Grijsen, R Steingrover, J N Vermeulen, M Nievaard, B Slegtenhorst, H Doevelaar, W Koevoets, H E Nobel, A Henderiks, F J J Pijnappel, M E van der Ende, B J A Rijnders, A Verbon, I Padmos, L van Zonneveld, S Been, R H Kauffmann, E F Schippers, R Korte, J M van Ijperen, Kennemer Gasthuis, R W ten Kate, R Soetekouw, N Hulshoff, M Schoemaker-Ransijn, F P Kroon, W Dorama, C A M Moons, S H Lowe, G Schreij, S van der Geest, A M Oude Lashof, J Schippers, W Bronsveld, G van Twillert, D van Houte, M G A van Vonderen, S Faber, S Rotteveel, C H H ten Napel, G J Kootstra, H Heins, Onze Lieve Vrouwe Gasthuis, K Brinkman, G E L van den Berk, W L Blok, P H J Frissen, W E M Schouten, L Schrijnders, A van Eeden, D W M Verhagen, M Groot, W Brokking, Slotervaart Ziekenhuis, J W Mulder, St Elisabeth Ziekenhuis, M E E van Kasteren, J R Juttmann, M Kuipers, St Lucas Andreas Ziekenhuis, J Veenstra, K D Lettinga, P P Koopmans, M Bosch, I M Hoepelman, T Mudrikova, I de Kroon

Affiliations

¹ Academic Medical Center, University of Amsterdam, Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam, Amsterdam, the Netherlands.
² Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands.
³ Academic Medical Center, University of Amsterdam, Department of Medical Microbiology, Amsterdam, the Netherlands.
⁴ Leiden University Medical Center, Department of Infectious Diseases, Leiden, the Netherlands.
⁵ Haga Hospital, location Leyenburg, Department of Internal Medicine, The Hague, the Netherlands.
⁶ Radboud University Medical Center, Department of Internal Medicine, Nijmegen, the Netherlands.
⁷ HIV Monitoring Foundation, Amsterdam, the Netherlands.

Abstract

Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI.

Publication types

Comparative Study

MeSH terms

Adult
Anti-HIV Agents / therapeutic use*
Drug Administration Schedule
Drug Resistance, Viral*
Female
Follow-Up Studies
HIV Infections / drug therapy*
HIV Infections / genetics
HIV Infections / virology*
HIV-1 / drug effects*
HIV-1 / genetics
Humans
Long-Term Care
Male
RNA, Viral / analysis
Viral Load / drug effects*

Substances

Anti-HIV Agents
RNA, Viral

Grants and funding

There are no current external funding sources for this study.