How Tets and cytoskeleton dynamics MET in reprogramming

Cell Stem Cell. 2014 Apr 3;14(4):417-8. doi: 10.1016/j.stem.2014.03.007.

Abstract

Two studies by Sakurai et al. (2014) and Hu et al. (2014) in this issue of Cell Stem Cell add a new level of understanding to the mesenchymal-to-epithelial transition taking place during reprogramming, showing how this morphological transformation is promoted by Tet enzymes and blocked by kinase-dependent cytoskeletal organization.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cellular Reprogramming / genetics*
  • Cytoskeleton / metabolism*
  • DNA Glycosylases / physiology*
  • DNA Methylation*
  • DNA-Binding Proteins / physiology*
  • Dioxygenases
  • Embryonic Stem Cells / cytology*
  • Epithelial-Mesenchymal Transition*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Protein Serine-Threonine Kinases / genetics*
  • Proto-Oncogene Proteins / physiology*

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • TET1 protein, mouse
  • Dioxygenases
  • Tet2 protein, mouse
  • Tet3 protein, mouse
  • Protein Serine-Threonine Kinases
  • DNA Glycosylases