Metabolic dysregulation in melanoma: cause or consequence?

Cancer Discov. 2014 Apr;4(4):390-1. doi: 10.1158/2159-8290.CD-14-0173.

Abstract

Parmenter and colleagues identify molecular pathways by which BRAF-MAPK signaling regulates glycolysis in melanoma, suggesting novel approaches to target these metabolic dependencies.

Publication types

  • Comment

MeSH terms

  • Glycolysis / drug effects*
  • Humans
  • Melanoma / genetics*
  • Protein Kinase Inhibitors / pharmacology*
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
  • Proto-Oncogene Proteins B-raf / genetics*

Substances

  • Protein Kinase Inhibitors
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf