Abstract
Twelve anaplastic thyroid carcinomas were investigated with a panel of antibodies. The squamoid and giant cell anaplastic carcinomas showed coexpression of cytokeratin and vimentin in 66% of the cases. Reactivity for A-1-AT and A-1-ACT antiserum appeared when the spindle cell component became prevalent. The antidesmoplakin antibody can be employed on cryostat sections in differential diagnosis between sarcoma and carcinoma of the thyroid.
MeSH terms
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Adult
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Aged
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Carcinoma / analysis*
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Carcinoma / diagnosis
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Carcinoma / pathology
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Carcinoma, Squamous Cell / analysis
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Carcinoma, Squamous Cell / diagnosis
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Cytoskeletal Proteins*
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Desmoplakins
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Diagnosis, Differential
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Female
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Humans
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Immunoenzyme Techniques
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Keratins / analysis
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Male
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Membrane Glycoproteins / analysis
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Middle Aged
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Thyroid Gland / pathology
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Thyroid Neoplasms / analysis*
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Thyroid Neoplasms / diagnosis
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Thyroid Neoplasms / pathology
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Vimentin / analysis
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alpha 1-Antichymotrypsin / analysis
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alpha 1-Antitrypsin / analysis
Substances
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Cytoskeletal Proteins
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Desmoplakins
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Membrane Glycoproteins
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Vimentin
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alpha 1-Antichymotrypsin
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alpha 1-Antitrypsin
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Keratins