Clinical characteristics and immunogenetics of BCGosis/BCGitis in Chinese children: a 6 year follow-up study

Wenjing Ying; Jinqiao Sun; Danru Liu; Xiaoying Hui; Yeheng Yu; Jingyi Wang; Xiaochuan Wang

doi:10.1371/journal.pone.0094485

Clinical characteristics and immunogenetics of BCGosis/BCGitis in Chinese children: a 6 year follow-up study

PLoS One. 2014 Apr 10;9(4):e94485. doi: 10.1371/journal.pone.0094485. eCollection 2014.

Authors

Wenjing Ying¹, Jinqiao Sun¹, Danru Liu¹, Xiaoying Hui¹, Yeheng Yu¹, Jingyi Wang¹, Xiaochuan Wang¹

Affiliation

¹ Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China.

Abstract

In this study, the clinical and immunogenetical features in a cohort of Chinese patients with BCGosis/BCGitis were investigated. For the patients with abnormal immunological functions, Sanger sequencing was used to identify the involved genes. There were 74 confirmed cases of BCGosis/BCGitis during 2007-2012. Classified by infected tissues and organs, no cases only had local infection, 39 patients had a regional infection, 21 patients had a distant infection and 14 patients had a disseminated infection. Thirty-two patients (43.2%) had definitive primary immunodeficiency diseases (PID) and chronic granulomatous disease (CGD) is the most common PID (n = 23, accounted for 71.9% of all PID patients). For CGD patients, based on the anti-tuberculosis treatment, administration of rhIFN-γ resulted in better control of BCGosis/BCGitis. The results indicate that PIDs are associated with susceptibility to BCG disease. For children with BCGosis/BCGitis, immune function evaluation is necessary, and IFN-γ treatment for BCGosis/BCGitis patients with CGD is effective.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

BCG Vaccine / administration & dosage
BCG Vaccine / adverse effects*
Child, Preschool
Female
Follow-Up Studies
Humans
Immunogenetics
Immunoglobulins / blood
Immunologic Deficiency Syndromes / immunology*
Immunologic Deficiency Syndromes / physiopathology
Infant
Infant, Newborn
Interferon-gamma / therapeutic use
Lymphocyte Subsets / immunology
Male
Mycobacterium Infections, Nontuberculous / drug therapy
Mycobacterium Infections, Nontuberculous / etiology
Mycobacterium Infections, Nontuberculous / immunology*
Mycobacterium Infections, Nontuberculous / physiopathology
Severity of Illness Index
Tuberculosis / prevention & control

Substances

BCG Vaccine
Immunoglobulins
Interferon-gamma

Supplementary concepts

BCG Infection, Generalized Familial

Grants and funding

This work was supported by National Natural Science Foundation of China (81172877) and Shanghai Rising-Star Program (11QA1400700). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.