Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency

J Allergy Clin Immunol. 2014 Jul;134(1):223-6. doi: 10.1016/j.jaci.2014.01.041. Epub 2014 Apr 14.

Authors

Janet Chou¹, Maxim Lutskiy¹, Erdyni Tsitsikov², Luigi D Notarangelo³, Raif S Geha⁴, Anahita Dioun¹

Affiliations

¹ Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass.
² Department of Laboratory Medicine, Boston Children's Hospital, Boston, Mass.
³ Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass; Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, Mass.
⁴ Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass. Electronic address: [email protected].

No abstract available

Publication types

Case Reports
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Agammaglobulinemia / complications
Agammaglobulinemia / genetics*
Agammaglobulinemia / immunology
Bacterial Infections / complications
Bacterial Infections / genetics*
Bacterial Infections / immunology
Down-Regulation
GATA2 Transcription Factor / deficiency*
GATA2 Transcription Factor / genetics
GATA2 Transcription Factor / immunology
Gene Expression
Humans
Immunity, Humoral
Immunoglobulin A / genetics
Immunoglobulin A / immunology
Immunoglobulin G / genetics
Immunoglobulin G / immunology
Opportunistic Infections / complications
Opportunistic Infections / genetics*
Opportunistic Infections / immunology

Substances

GATA2 Transcription Factor
GATA2 protein, human
Immunoglobulin A
Immunoglobulin G

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