Evaluation of avibactam-supplemented combination disk tests for the detection of OXA-48 carbapenemase-producing Enterobacteriaceae

Diagn Microbiol Infect Dis. 2014 Jun;79(2):252-4. doi: 10.1016/j.diagmicrobio.2014.03.010. Epub 2014 Mar 18.

Abstract

The ability of various combination disk tests (CDTs) incorporating avibactam to detect OXA-48 carbapenemase-producing Enterobacteriaceae was evaluated. The CDT using 30-μg temocillin alone and supplemented with 5-μg avibactam showed good performance and could be an adjunctive test to the classic CDT containing class A and class B carbapenemase inhibitors for the positive discrimination of OXA-48 carbapenemase producers from carbapenemase-negative strains.

Keywords: Inhibitor; OXA-type beta-lactamase; Temocillin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents*
  • Azabicyclo Compounds*
  • Bacteriological Techniques / methods*
  • Enterobacteriaceae / drug effects*
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / diagnosis
  • Enterobacteriaceae Infections / microbiology
  • Humans
  • Penicillins
  • beta-Lactamases / analysis*

Substances

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Penicillins
  • temocillin
  • avibactam
  • beta-Lactamases
  • oxacillinase