Molecular modelling approaches for cystic fibrosis transmembrane conductance regulator studies

Norbert Odolczyk; Piotr Zielenkiewicz

doi:10.1016/j.biocel.2014.04.004

Molecular modelling approaches for cystic fibrosis transmembrane conductance regulator studies

Int J Biochem Cell Biol. 2014 Jul:52:39-46. doi: 10.1016/j.biocel.2014.04.004. Epub 2014 Apr 13.

Authors

Norbert Odolczyk¹, Piotr Zielenkiewicz²

Affiliations

¹ Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warszawa, Poland.
² Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warszawa, Poland; Faculty of Biology, Warsaw University, 02-106 Warszawa, Poland. Electronic address: [email protected].

PMID: 24735712
DOI: 10.1016/j.biocel.2014.04.004

Abstract

Cystic fibrosis (CF) is one of the most common genetic disorders, caused by loss of function mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein. CFTR is a member of ATP-binding cassette (ABC) transporters superfamily and functions as an ATP-gated anion channel. This review summarises the vast majority of the efforts which utilised molecular modelling approaches to gain insight into the various aspects of CFTR protein, related to its structure, dynamic properties, function and interactions with other protein partners, or drug-like compounds, with emphasis to its relation to CF disease.

Keywords: CFTR; Cystic fibrosis; In silico studies; Molecular modelling.

Publication types

Review

MeSH terms

Animals
Cystic Fibrosis / genetics
Cystic Fibrosis / metabolism*
Cystic Fibrosis Transmembrane Conductance Regulator / chemistry*
Cystic Fibrosis Transmembrane Conductance Regulator / genetics
Cystic Fibrosis Transmembrane Conductance Regulator / metabolism*
Humans
Models, Molecular

Substances

Cystic Fibrosis Transmembrane Conductance Regulator