1 Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany, and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany, and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.