Vaginal myeloid dendritic cells transmit founder HIV-1

J Virol. 2014 Jul;88(13):7683-8. doi: 10.1128/JVI.00766-14. Epub 2014 Apr 16.

Abstract

We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13(+) CD11c(+) DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Dendritic Cells / metabolism
  • Dendritic Cells / virology*
  • Female
  • HIV Infections / metabolism
  • HIV Infections / transmission*
  • HIV-1 / pathogenicity*
  • Humans
  • Myeloid Cells / metabolism
  • Myeloid Cells / virology*
  • Receptors, CCR5 / metabolism
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / virology*
  • Vagina / metabolism
  • Vagina / virology*

Substances

  • Receptors, CCR5