Pluripotency: citrullination unravels stem cells

Nat Chem Biol. 2014 May;10(5):327-8. doi: 10.1038/nchembio.1504.

Abstract

Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones. The discovery that citrullination of the linker histone H1 is critical to this process represents a new role for the protein arginine deiminases (PADs) in development.

Publication types

  • News

MeSH terms

  • Animals
  • Citrulline / metabolism*
  • Histones / metabolism
  • Hydrolases / metabolism
  • Mice
  • Pluripotent Stem Cells / metabolism*
  • Protein Processing, Post-Translational
  • Protein-Arginine Deiminase Type 4
  • Protein-Arginine Deiminases

Substances

  • Histones
  • Citrulline
  • Hydrolases
  • Protein-Arginine Deiminase Type 4
  • Protein-Arginine Deiminases
  • peptidylarginine deiminase 4, mouse