Globally, Cryptococcosis is the most common invasive mycosis in HIV disease. Incidence rates vary widely by geographical region and resource availability and reportedly range from 0.04 to 12% per year (1). Sub-Saharan Africa accounts for the greatest burden with a median incidence of 3.2% per year (1). Since the advent of widespread use of antiretroviral therapy (ART), incidence rates of opportunistic infections have been significantly declining (2).