Abstract
Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic, antioxidant, antiallergic, antimicrobial, antinematodal, and acetylcholinesterase inhibitory properties. Dibenzo-α-pyrones are biosynthesized via the polyketide pathway in microorganisms or metabolized from plant-derived ellagitannins and ellagic acid by intestinal bacteria. At least 53 dibenzo-α-pyrones have been reported in the past few decades. This mini-review aims to briefly summarize the occurrence, biosynthesis, biotransformation, as well as their biological activities and functions. Some considerations related to synthesis, production and applications of dibenzo-α-pyrones are also discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Allergic Agents / chemistry*
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Anti-Allergic Agents / isolation & purification
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Anti-Allergic Agents / metabolism
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Anti-Allergic Agents / pharmacology
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / metabolism
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Anti-Infective Agents / pharmacology
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / metabolism
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Antioxidants / pharmacology
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Bacteria / chemistry
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Bacteria / metabolism
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Benzopyrans / chemistry*
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Benzopyrans / isolation & purification
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Benzopyrans / metabolism
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Benzopyrans / pharmacology
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Biological Products / chemistry*
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Biological Products / isolation & purification
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Biological Products / metabolism
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Biological Products / pharmacology
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Biotransformation
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Feces / chemistry
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Fungi / chemistry
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Fungi / metabolism
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Humans
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Plants / chemistry
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Plants / metabolism
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Pyrones / chemistry*
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Pyrones / isolation & purification
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Pyrones / metabolism
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Pyrones / pharmacology
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Structure-Activity Relationship
Substances
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Anti-Allergic Agents
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Anti-Infective Agents
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Antioxidants
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Benzopyrans
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Biological Products
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Pyrones