Avidity of antibodies against infecting pneumococcal serotypes increases with age and severity of disease

Amelieke J H Cremers; Jonneke Lut; Peter W M Hermans; Jacques F Meis; Marien I de Jonge; Gerben Ferwerda

doi:10.1128/CVI.00147-14

Avidity of antibodies against infecting pneumococcal serotypes increases with age and severity of disease

Clin Vaccine Immunol. 2014 Jun;21(6):904-7. doi: 10.1128/CVI.00147-14. Epub 2014 Apr 23.

Authors

Amelieke J H Cremers¹, Jonneke Lut², Peter W M Hermans², Jacques F Meis³, Marien I de Jonge², Gerben Ferwerda²

Affiliations

¹ Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands [email protected].
² Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands.
³ Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands.

Abstract

The incidence of invasive pneumococcal disease (IPD) rises with age. Among adult IPD patients, the avidity of antipneumococcal polysaccharide antibodies against the infecting serotype increased with age and severity of disease, indicating that susceptibility to IPD in the elderly may rather be due to flaws in other aspects of opsonophagocytosis.

MeSH terms

Aging
Antibodies, Bacterial / immunology*
Antibody Affinity / immunology*
Humans
Immunoglobulin G / blood*
Immunoglobulin G / immunology*
Pneumococcal Infections / immunology
Polysaccharides, Bacterial / immunology
Severity of Illness Index
Streptococcus pneumoniae / immunology

Substances

Antibodies, Bacterial
Immunoglobulin G
Polysaccharides, Bacterial