Abstract
Pantothenol is a provitamin of pantothenic acid (vitamin B5) that is widely used in healthcare and cosmetic products. This analog of pantothenate has been shown to markedly inhibit the phosphorylation activity of the prokaryotic type II pantothenate kinase of Staphylococcus aureus, which catalyzes the first step of the coenzyme A biosynthetic pathway. Since type II enzymes are found exclusively in staphylococci, pantothenol suppresses the growth of S. aureus, S. epidermidis, and S. saprophyticus, which inhabit the skin of humans. Therefore, the addition of this provitamin to ointment and skincare products may be highly effective in preventing infections by opportunistic pathogens.
MeSH terms
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Amino Acid Sequence
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Anti-Infective Agents / pharmacology*
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Bacterial Proteins / antagonists & inhibitors
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Biosynthetic Pathways / drug effects
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Coenzyme A / biosynthesis
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Escherichia coli K12 / drug effects
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Escherichia coli K12 / enzymology
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Escherichia coli K12 / growth & development
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Humans
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Microbial Sensitivity Tests
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Pantothenic Acid / analogs & derivatives*
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Pantothenic Acid / chemistry
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Pantothenic Acid / pharmacology
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Phosphorylation / drug effects
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Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors*
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Pseudomonas putida / drug effects
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Pseudomonas putida / enzymology
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Pseudomonas putida / growth & development
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcus / drug effects*
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Staphylococcus / enzymology
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Staphylococcus / growth & development
Substances
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Anti-Infective Agents
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Bacterial Proteins
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Pantothenic Acid
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dexpanthenol
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Phosphotransferases (Alcohol Group Acceptor)
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pantothenate kinase
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Coenzyme A