[Treatment of scabies and Ascabiol(®) supply disruption: what about the pediatric population?]

A Berthe-Aucejo; S Prot-Labarthe; L Pull; M Lorrot; S Touratier; H Trout; O Bourdon; L Dehen; E Bourrat

doi:10.1016/j.arcped.2014.03.001

[Treatment of scabies and Ascabiol(®) supply disruption: what about the pediatric population?]

Arch Pediatr. 2014 Jun;21(6):670-5. doi: 10.1016/j.arcped.2014.03.001. Epub 2014 Apr 24.

[Article in French]

Authors

A Berthe-Aucejo¹, S Prot-Labarthe², L Pull³, M Lorrot⁴, S Touratier⁵, H Trout⁶, O Bourdon⁷, L Dehen⁸, E Bourrat⁹

Affiliations

¹ Service de pharmacie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
² Service de pharmacie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France. Electronic address: [email protected].
³ Service d'urgences pédiatriques, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
⁴ Service de pédiatrie générale, faculté de médecine Denis-Diderot (Paris VII), hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
⁵ Service de pharmacie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux 75010 Paris, France.
⁶ Service de pharmacie, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.
⁷ Service de pharmacie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Faculté de pharmacie, université Paris Descartes (Paris V), 1, avenue Claude-Vellefaux, 75010 Paris, France; Laboratoire éducation et pratiques de santé, université Paris XIII, Bobigny, France.
⁸ Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France.
⁹ Service de pédiatrie générale, faculté de médecine Denis-Diderot (Paris VII), hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France.

PMID: 24768069
DOI: 10.1016/j.arcped.2014.03.001

Abstract

Scabies is a disease in steady increase in Île-de-France region. Standard treatment, Ascabiol(®) (benzyl benzoate/sulfiram), is back-order for several months and its return remains uncertain. Facing this drug shortage, French Drug Agency (ANSM) has imported a drug from Germany, Antiscabiosum 10 % (benzyl benzoate), to treat patients having contraindications for other scabicides available in France (ivermectin, esdepallethrine). However, infants less than 1 year (<15 kg) and asthmatics infants have no alternative treatment. A multidisciplinary workgroup explored the various existing therapeutic alternatives in France and worldwide. From ANSM's recommendations and group's experience, a decision algorithm was proposed for treating patients. However, pediatric context implied the use of off-label drugs. Proposed treatments widely known by practitioners, prescriptions-types, dose, modalities of use and dispensation, and flyers to patients were realized to optimize treatment efficacy.

Publication types

English Abstract

MeSH terms

Benzoates / supply & distribution*
Benzoates / therapeutic use
Child
Disinfection
France
Government Agencies
Humans
Insecticides / supply & distribution*
Insecticides / therapeutic use*
Ivermectin / therapeutic use
Permethrin / therapeutic use
Scabies / drug therapy*

Substances

Benzoates
Insecticides
Permethrin
Ivermectin
benzyl benzoate