Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Biomaterials. 2014 Jul;35(22):5840-6. doi: 10.1016/j.biomaterials.2014.04.004. Epub 2014 Apr 24.

Abstract

Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.

Keywords: (18)F; Aluminium hydroxide; Dual-modal; MR; Magnetic nanoparticles; PET.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum Hydroxide* / chemistry
  • Animals
  • Contrast Media* / chemistry
  • Female
  • Ferric Compounds* / chemistry
  • Ferrosoferric Oxide* / chemistry
  • Fluorine Radioisotopes / chemistry
  • Magnetic Resonance Imaging
  • Manganese Compounds* / chemistry
  • Mice
  • Nanoparticles* / chemistry
  • Positron-Emission Tomography

Substances

  • Contrast Media
  • Ferric Compounds
  • Fluorine Radioisotopes
  • Manganese Compounds
  • manganese ferrite
  • Aluminum Hydroxide
  • Ferrosoferric Oxide