Abstract
A new series of phenylalkylamines related to Verapamil have been synthesized and their Ca2+-modulating activity on rabbit aorta and on guinea-pig heart were evaluated. The compounds display only a moderate Ca2+-antagonistic activity; none of them showed any Ca2+-agonistic effect.
MeSH terms
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology
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Animals
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Calcium Channel Agonists / chemical synthesis*
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Calcium Channel Agonists / pharmacology
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Chemical Phenomena
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Chemistry
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Female
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Guinea Pigs
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Heart / drug effects
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Heart Rate / drug effects
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects
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Rabbits
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Verapamil / analogs & derivatives*
Substances
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Calcium Channel Agonists
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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Verapamil