Stevens-Johnson syndrome, respiratory distress and acute renal failure due to synergic bleomycin-cisplatin toxicity

J Clin Pharmacol. 1989 Sep;29(9):821-3. doi: 10.1002/j.1552-4604.1989.tb03426.x.

Abstract

A patient presenting with a cervix uteri epidermoid carcinoma had acute renal failure after treatment with cisplatin and bleomycin. She later developed fatal bleomycin-induced pneumonitis and Stevens-Johnson syndrome. This is a very rare association of adverse effects. The risk of causing a drug interaction thus increasing the severity of bleomycin undesired effects must be taken into account when a nephrotoxic drug is added to the former. The authors stress the importance of monitoring renal function under these conditions.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / pathology
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bleomycin / administration & dosage
  • Bleomycin / adverse effects
  • Carcinoma, Squamous Cell / drug therapy
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects
  • Female
  • Humans
  • Infant, Newborn
  • Middle Aged
  • Respiratory Distress Syndrome, Newborn / chemically induced*
  • Respiratory Distress Syndrome, Newborn / pathology
  • Stevens-Johnson Syndrome / chemically induced*
  • Stevens-Johnson Syndrome / pathology
  • Uterine Cervical Neoplasms / drug therapy

Substances

  • Bleomycin
  • Cisplatin